Histamine H2 receptors and gastric acid secretion in the stomach

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H2 receptors are responsible for stimulating the secretion of gastric acid in the stomach.

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When histamine binds to these receptors on parietal cells in the stomach lining, it triggers the production of hydrochloric acid.

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H2 receptor antagonist drugs like cimetidine, ranitidine, famotidine block the action of histamine at the histamine H2 receptors, thereby reducing gastric acid secretion.

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